The Pain and Performance Podcast

What Really Happens When You Fast?

Derrick Hines

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0:00 | 9:47

Fasting is not just about weight loss. In this episode, Dr. Derrick Hines breaks down what actually happens inside your body when you stop eating. He explains the metabolic switch from glucose to fat, the rise in ketones, and why hitting the 72-hour mark unlocks autophagy, your body’s built-in cellular cleanup system. From reducing inflammation and improving insulin sensitivity to increasing natural stem cell production, fasting can act as a powerful metabolic reset. Dr. Hines also shares why he often prefers a fasting-mimicking approach over water-only fasting, especially to protect muscle and hormone balance.

In This Episode

-- Why fasting is more than calorie restriction

-- The 12 to 24 hour metabolic shift explained

-- When ketones rise and why that matters

-- What autophagy is and why it’s a cellular superpower

-- The connection between fasting, inflammation, and stem cells

-- How fasting supports metabolic health and insulin sensitivity

-- Why Dr. Hines recommends fasting mimicking over water-only fasts


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